Key result
A genome-wide association study identified one SNP on chromosome 37 significantly associated with dilated cardiomyopathy in Irish wolfhounds (OR 1.73), located near lipid metabolism genes MOGAT1 and ACSL3.
Why the study?
Are specific genetic loci associated with dilated cardiomyopathy in Irish wolfhounds?
Case-Control (n=190)
Yes
Are specific genetic loci associated with dilated cardiomyopathy in Irish wolfhounds?
Multiple genetic loci, including one near lipid metabolism genes MOGAT1 and ACSL3, are associated with dilated cardiomyopathy in Irish wolfhounds, suggesting an oligogenic inheritance pattern.
May inform breeding programs in Irish wolfhounds; hypothesis-generating for lipid pathways in canine DCM, pending replication.
Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we identified one SNP significantly associated with DCM on CFA37 and five SNPs suggestively associated with DCM on CFA1, 10, 15, 21 and 17. On CFA37 MOGAT1 and ACSL3 two enzymes of the lipid metabolism were located near the identified SNP.
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Philipp et al. (2012) conducted a case-control in Dilated cardiomyopathy (n=190). Genetic loci variants (e.g., SNP BICF2G630134189 on CFA37) vs. Reference alleles was evaluated on Association of single nucleotide polymorphisms (SNPs) with dilated cardiomyopathy (OR 1.73, 95% CI 1.14-2.61, p=<0.00001). A genome-wide association study identified one SNP on chromosome 37 significantly associated with dilated cardiomyopathy in Irish wolfhounds (OR 1.73), located near lipid metabolism genes MOGAT1 and ACSL3.
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