Key result
Natural progression of aortic stenosis in boxer dogs resulted in a >20% increase in aortic velocity in 17% of dogs and new echocardiographic changes in 23% upon re-evaluation.
Cohort (n=35)
No
Aortic stenosis in boxer dogs demonstrates progressive clinical and echocardiographic worsening over time in a subset of affected animals.
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Serial echocardiography may detect progression in boxer dogs with aortic stenosis; leaves open optimal monitoring intervals and intervention thresholds.
Thirty-five boxers that had been referred to the Royal (Dick) School of Veterinary Studies between 1989 and 1994 with left heart base murmurs and aortic velocities greater than 1.5 m/second on Doppler echocardiography were recalled for clinical examination and Doppler echocardiography between 1995 and 1996. Five dogs (14 per cent) showed an increase in murmur grade on repeat visit. Six dogs (17 per cent) showed an increase in aortic velocity of greater than 20 per cent. Eight dogs (23 per cent) had developed aortic valvular or subvalvular two-dimensional echocardiographic changes that had not been present at the initial visit. Seven dogs (20 per cent) had developed aortic regurgitation, and three dogs (8 per cent) mitral regurgitation.
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French et al. (2000) conducted a cohort in Aortic stenosis (n=35). Natural progression vs. Baseline was evaluated on Increase in aortic velocity of greater than 20 per cent. Natural progression of aortic stenosis in boxer dogs resulted in a >20% increase in aortic velocity in 17% of dogs and new echocardiographic changes in 23% upon re-evaluation.
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