Key result
The VEGF C allele was significantly more frequent in endurance athletes compared to controls and correlated with higher aerobic performance, suggesting a role in sports selection.
Why the study?
Is the G-634C polymorphism of the VEGF gene associated with aerobic performance in athletes?
Case-Control (n=1,743)
Is the G-634C polymorphism of the VEGF gene associated with aerobic performance in athletes?
The G-634C polymorphism of the VEGF gene is associated with enhanced aerobic performance and may play a role in sports selection.
VEGF C allele association with endurance is hypothesis-generating; leaves open any role in athlete selection or training without prospective validation.
The subject of this study is the frequency distribution of alleles of the vascular endothelial growth factor gene (VEGF; the G-634C polymorphism) in athletes (n = 670) and in a control group (n = 1073) and the relationships of genotypes with aerobic performance in rowers (n = 90). Genetic typing was performed using the analysis of restriction fragment length polymorphism. The frequency of the VEGF C allele in the group of endurance athletes (n = 294) was significantly higher than in the control group and increased together with increasing sports qualification. In addition, a correlation of the VEGF C allele with a high aerobic performance of athletes (according to data on the maximal power and maximal oxygen consumption) and with a substantial contribution to the energy supply of aerobic metabolism (according to the values of maximal lactate content) has been found. It is inferred that the G-634C polymorphism of the VEGF gene is associated with physical performance of athletes and plays a key role in sports selection.
No takes yet. Share an insight, caveat, or question.
Ahmetov et al. (2008) conducted a case-control in Athletic performance (n=1,743). VEGF gene G-634C polymorphism (C allele) vs. Control group was evaluated on Frequency of VEGF C allele and correlation with aerobic performance. The VEGF C allele was significantly more frequent in endurance athletes compared to controls and correlated with higher aerobic performance, suggesting a role in sports selection.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: