Key result
L-carnitine supplementation did not affect the immunohistochemical expression of MMP-2, MMP-9, TIMP-1, or TIMP-2 in a rat model of choline deficiency-induced cardiomyopathy.
Why the study?
Does carnitine supplementation affect MMP and TIMP expression in a rat model of choline deficiency-induced cardiomyopathy?
Population
Male Wistar Albino adult rats
Comparison
Choline-deficient diet with or without… vs Standard diet with or without L-carnitine
Design
Preclinical
Follow-up
1 month
Authors
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Profibrotic MMP/TIMP modulation not reversed by carnitine; leaves open its role in choline deficiency cardiomyopathy.
Does carnitine supplementation affect MMP and TIMP expression in a rat model of choline deficiency-induced cardiomyopathy?
In a rat model of choline deficiency-induced cardiomyopathy, the observed profibrotic pattern of MMP and TIMP modulation is not reversed by carnitine supplementation.
Strilakou et al. (2015) studied Choline deficiency-induced cardiomyopathy. L-carnitine vs. No L-carnitine was evaluated on Immunohistochemical expression of MMP-2, MMP-9, TIMP-1, and TIMP-2. L-carnitine supplementation did not affect the immunohistochemical expression of MMP-2, MMP-9, TIMP-1, or TIMP-2 in a rat model of choline deficiency-induced cardiomyopathy.
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