Key result
The IL28B rs129679860 CC genotype was associated with a higher sustained virological response (62%) compared to CT (33%) and TT (18%) genotypes in HCV genotype-1 patients (p=0.016).
Why the study?
Does the IL28B SNP rs129679860 predict sustained virological response in chronic HCV genotype-1 patients treated with pegylated interferon-ribavirin?
Population
66 naïve genotype-1 chronic HCV-monoinfected patients in Brazil
Comparison
Pegylated interferon-ribavirin treatment and… vs Different genotypes
Design
Cohort
Authors
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Should not yet guide therapy; extends IL28B-SVR association to Brazilian HCV-1 patients but remains hypothesis-generating.
Cohort (n=66)
Does the IL28B SNP rs129679860 predict sustained virological response in chronic HCV genotype-1 patients treated with pegylated interferon-ribavirin?
Absolute Event Rate: 62% vs 18%
p-value: p=0.016
The single nucleotide polymorphism rs129679860 in the IL28B locus successfully predicts sustained virological response in Brazilian patients with chronic HCV genotype-1 treated with pegylated interferon-ribavirin.
Ramos et al. (2012) conducted a cohort in chronic hepatitis C virus genotype-1 monoinfection (n=66). rs129679860 CC genotype vs. TT genotype was evaluated on Sustained virological response (SVR) (p=0.016). The IL28B rs129679860 CC genotype was associated with a higher sustained virological response (62%) compared to CT (33%) and TT (18%) genotypes in HCV genotype-1 patients (p=0.016).
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