Hepatic-Vein Thrombosis After Chemotherapy for Histiocytoma

Letters and Corrections1 April 1978Hepatic-Vein Thrombosis After Chemotherapy for HistiocytomaL. M. LEHRNER, PH.D., M.D., ROBERT E. ENCK, M.D.L. M. LEHRNER, PH.D., M.D.Search for more papers by this author, ROBERT E. ENCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-575_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently, combination chemotherapy with cytarabine and 6-thioguanine has been associated with the development of hepatic veno-occlusive disease (hepatic-vein thrombosis, Budd-Chiari syndrome) (1, 2). We wish to report a case of retroperitoneal malignant fibrous histiocytoma in which hepatic-vein thrombosis developed after combination chemotherapy with doxorubicin, dacarbazine, vincristine, and cyclophosphamide.A 46-year-old white man underwent an exploratory laparotomy for diagnosis of an abdominal mass. At surgery, an unresectable malignant fibrous histiocytoma was found between the leaves of the small-bowel mesentery. One month later, the first course of chemotherapy was administered and was followed in 3 weeks by a second...References1. GRINERELBADAWIPACKMAN PAC: Veno-occlusive disease of the liver after chemotherapy of acute leukemia. Report of two cases. Ann Intern Med 85:578-582, 1976 LinkGoogle Scholar2. WASSERCOLEMAN JM: Leukemia chemotherapy and centrilobular hepatic necrosis. Ann Intern Med 86:508-509, 1977 LinkGoogle Scholar3. PARKER R: Occlusion of the hepatic veins in man. Medicine (Baltimore) 38:369-397, 1959 CrossrefMedlineGoogle Scholar4. CHABNERMYERSOLIVERIO BCV: Clinical pharmacology of anticancer drugs. Semin Oncol 4:165-191, 1977 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: William Beaumont Army Medical Center El Paso, TX 79920 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHepatotoxicity of ChemotherapyVascular Toxicity of Antineoplastic AgentsHepatotoxicity of chemotherapyHepatotoxicity of ChemotherapyHEPATOTOXICITY OF CHEMOTHERAPEUTIC AND ONCOLOGIC AGENTSPrevention of postoperative thromboembolic complications in a patient with budd-chiari syndrome and acquired protein C deficiency by short-term administration of protein C concentratesAcute Budd-Chiari syndrome with hepatic failure and obstruction of the inferior vena cava as presenting manifestations of hereditary protein C deficiency.Fatal hepatic vascular toxicity of DTIC.Is it really a rare event?12 Drug-induced vascular and sinusoidal lesions of the liverHepatic veno-occlusive diseaseVeno-occlusive liver disease after dacarbazine therapy (DTIC) for melanomaVeno-occlusive disease of the liver after high-dose mitomycin C therapy and autologous bone marrow transplantationHepatic vascular lesions associated with dacarbazine treatment.Veno-occlusives Syndrom mit akuter Leberdystrophie unter Dacarbazin-Therapie eines malignen MelanomsHepatic veno-occlusive disease due to DTICHepatic failure in a patient treated with dacarbazine (DTIC) for malignant melanoma 1 April 1978Volume 88, Issue 4Page: 575-576KeywordsChemotherapyCombination chemotherapyCyclophosphamideLaparotomySurgeryThrombosis Issue Published: 1 April 1978 PDF DownloadLoading ...