Key result
Prompt administration of reversal agents in patients with warfarin-induced major bleeding increases coagulation factors, but mortality remains high.
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High mortality persists despite reversal; leaves open whether adjunctive strategies or prevention reduce deaths in warfarin bleeding.
Background In patients with warfarin-induced major bleeding, prompt administration of reversal agents increases coagulation factors and may allow early surgical correction of bleeding. However even with reversal agents, mortality is high. In this analysis the type and timing of reversal agents were evaluated
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Jad et al. (2014) studied this question. Prompt administration of reversal agents in patients with warfarin-induced major bleeding increases coagulation factors, but mortality remains high.
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