Impact of Skin Autofluorescence on High Sensitivity Troponin T in Japanese Patients with Obesity

Background : Skin autofluorescence (AF) is known to be a risk factor for various diseases.However, no studies have reported a correlation between skin AF and high sensitivity troponin T (hs-cTnT) in patients with obesity.The aim of this study was to clarify the impact of skin AF on hs-cTnTin Japanese patients with obesity from perspective of primary prevention of cardiovascular disease.Methods: Japanese patients with obesity [body mass index ≥25 kg/m 2 , N = 419, 255 males and 164 females; mean age, 66 ± 12 years (mean ± standard deviation)] without a history of cardiovascular events were enrolled in the study.Hs-cTnT levels and skin AF were measured using commercial device, and relationships between hs-cTnT levels and various clinical parameters including skin AF were examined.Results: Hs-cTnT was detected in 345 (82.3%) patients.Skin AF was significantly higher in patients with detectable hs-cTnT than in those without detectable hs-cTnT (2.6 ± 0.5 AU vs. 2.2 ± 0.4 AU, respectively, P < 0.001).In patients with detectable hs-cTnT, there was a significantly positive correlation between skin AF and hs-cTnT (r = 0.31, P < 0.001).Furthermore, multiple regression analyses revealed that the cardio-ankle vascular index was a marker of arterial function; blood concentrations of brain natriuretic peptide, skin AF, reactive oxygen metabolites as markers of oxidative stress, body mass index, and age were selected as independent variables when hs-cTnT was used as a subordinate factor.Conclusions: These results indicate that skin AF reflects hs-cTnT levels in Japanese patients with obesity.