Key result
High sensitivity cardiac troponin T was detected in 64% of patients and significantly correlated with systolic blood pressure (P=0.007), diastolic blood pressure (P=0.006), hypertension (P=0.006), and truncal fat (P=0.001).
Why the study?
T2DM predisposes to diabetic cardiomyopathy and CVD, and hs-cTnT can identify patients at risk for cardiovascular issues, motivating evaluation of its relation to hypertension and truncal obesity in T2DM.
Is high-sensitive cardiac troponin T associated with hypertension and truncal obesity in patients with Type 2 Diabetes Mellitus?
Cohort (n=50)
Yes
Is high-sensitive cardiac troponin T associated with hypertension and truncal obesity in patients with Type 2 Diabetes Mellitus?
p-value: p=0.007, 0.006, 0.006, 0.001
In patients with type 2 diabetes, elevated hs-cTnT is significantly correlated with hypertension and truncal obesity, suggesting its utility as a biomarker for cardiometabolic risk.
Background: Diabetes mellitus type 2 (T2DM) is a prevalent metabolic disease that predisposes to diabetic cardiomyopathy and cardiovascular diseases (CVD). High sensitivity cardiac troponin T (hs-cTnT) can determine who is most at risk for developing cardiovascular issues and diabetes. Objective: To evaluate the relation between high-sensitive cardiac troponin T and cardiac metabolic risks (hypertension and truncal obesity) in patient with T2DM. Patients and Methods: A prospective cohort study included 50 diabetic patients reached at the emergency units of Mansoura University Hospital and Al-Azhar University Hospital in Egypt, for one year-duration from May 2021 to May 2022. All of the patients had been subjected to physical examination, medical and family diabetes history. Laboratory tests, included hs-cTnT, and truncal obesity measurement also were reported. Results: The biomarker hs-cTnT was found in 32 (64%) of the patients. A strong significant correlation was detected between hs-cTnT and systolic blood pressure (SBP), diastolic blood pressure (DBP), hypertension, and truncal fat by dual-emission X-ray absorptiometry (DXA); with p-value (0.007, 0.006, 0.006, 0.001) respectively. Besides, no significant correlation was detected between hs-cTnT and the duration of diabetes, RBG, HBA1c, and BMI. Furthermore, the mean truncal fat of study population that detected by DXA scan was ranged from 8 Kg to 24 Kg with mean + SD = 14.5 + 4.51 Kg. Conclusion: The biomarker hs-cTnT and truncal fat might be associated with cardiac metabolic risks in patient with T2DM.
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Asy et al. (2023) conducted a cohort in Type 2 Diabetes Mellitus (n=50). High sensitivity cardiac troponin T (hs-cTnT) was evaluated on Correlation with systolic blood pressure, diastolic blood pressure, hypertension, and truncal fat (p=0.007, 0.006, 0.006, 0.001). High sensitivity cardiac troponin T was detected in 64% of patients and significantly correlated with systolic blood pressure (P=0.007), diastolic blood pressure (P=0.006), hypertension (P=0.006), and truncal fat (P=0.001).
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