Key result
Elevated hs-cTnT linked to ~661% higher risk of lower limb disease in diabetic adults.
Why the study?
To evaluate the association of hypersensitive cardiac troponin (hs-cTnT), a biomarker of myocardial injury, with diabetic lower extremity disease in American adults.
Is high-sensitivity cardiac troponin T (hs-cTnT) associated with lower extremity disease in diabetic adults?
Cross-Sectional (n=1,196)
Yes
Is high-sensitivity cardiac troponin T (hs-cTnT) associated with lower extremity disease in diabetic adults?
Odds Ratio: 7.607 (95% CI 7.574–7.64)
Absolute Event Rate: 70.4% vs 22.8%
p-value: p=<0.0001
High-sensitivity cardiac troponin T (hs-cTnT) is significantly associated with lower extremity disease in diabetic adults, highlighting its potential utility as a biomarker, though chronic kidney disease acts as a strong interacting factor.
hs-cTnT was associated with lower limb lesions in diabetes; hypothesis-generating and requires prospective validation before biomarker use.
Objective: To evaluate the association of hypersensitive cardiac troponin (hs-cTnT), a biomarker of myocardial injury, with diabetic lower extremity disease in American adults. Methods: We conducted a cross-sectional study (unweighted N=1,196) of diabetic patients aged 40 years or older who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004. Logistic regression was used to assess the association of hs-cTnT with lower extremity disease, including peripheral neuropathy (as assessed by monofilament test), peripheral artery disease (as assessed by ankle-brachial index), history of foot ulcers, or amputation. All analyses are weighted. Results: The prevalence rate of diabetic lower extremity disease was 41.6%. Adjusted hs-cTnT was significantly associated with lower limb disease in adults with diabetes. There is interaction between chronic kidney disease and hs-cTnT, which strongly interferes with the correlation between hs-cTnT and lower extremity lesions in diabetic patients. Conclusions: Our study suggests the usefulness of hs-cTnT as a biomarker for lower extremity lesions in adults with diabetes and highlights the potential direct interaction of hs-cTnT with chronic kidney disease.
No takes yet. Share an insight, caveat, or question.
Li et al. (2025) conducted a cross-sectional in Diabetes mellitus with lower limb disease (n=1,196). High-sensitivity cardiac troponin T (hs-cTnT) vs. Lower hs-cTnT levels (≤5.85 ng/L) was evaluated on Presence of any lower limb disease (peripheral neuropathy, peripheral arterial disease, or history of foot ulcers/amputations) (OR 7.607, 95% CI 7.574-7.640, p=<0.0001). Higher levels of high-sensitivity cardiac troponin T (>15.08 ng/L) were significantly associated with an increased risk of lower limb disease in adults with diabetes (OR 7.607) compared to levels ≤5.85 ng/L.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: