Key result
Baseline type 2 diabetes was significantly associated with elevated high sensitivity cardiac troponin T levels over 5 years of follow-up (HR 2.492), driven primarily by postprandial blood glucose.
Why the study?
Does baseline type 2 diabetes associate with elevated high sensitivity cardiac troponin T levels in a Chinese community-dwelling population without CAD?
Cohort (n=730)
Yes
Does baseline type 2 diabetes associate with elevated high sensitivity cardiac troponin T levels in a Chinese community-dwelling population without CAD?
Baseline type 2 diabetes, driven primarily by postprandial blood glucose, is significantly associated with elevated high-sensitivity cardiac troponin T levels over 5 years in a Chinese community-dwelling population without CAD.
BACKGROUND: The present analysis was designed to investigate the association of type 2 diabetes (T2D) with high sensitivity cardiac troponin T (hs-cTnT) during the 5 years of follow-up, and explore which one of fasting blood glucose (FBG) and postprandial blood glucose (PBG) is a determinant of this association in Chinese community-dwelling population. METHODS: This prospective community-based analysis was conducted based on 730 participants without coronary artery disease and hs-cTnT values ≥14 pg/mL receiving two measurements of hs-cTnT levels at baseline and follow-up of 5 years. CONCLUSIONS: This community-based analysis observed that there was a significant increment of hs-cTnT levels, and baseline T2D had a significant association with elevated hs-cTnT levels during the 5 years of follow-up. Moreover, the present analysis demonstrated that PBG rather than FBG played a crucial role in this association in Chinese community-dwelling population without CAD.
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Fu et al. (2017) conducted a cohort in Community-dwelling population without coronary artery disease (n=730). Baseline type 2 diabetes vs. Without type 2 diabetes was evaluated on Elevated high sensitivity cardiac troponin T (hs-cTnT) levels ≥14 pg/mL at follow-up (HR 2.492, 95% CI 1.270-4.892, p=0.008). Baseline type 2 diabetes was significantly associated with elevated high sensitivity cardiac troponin T levels over 5 years of follow-up (HR 2.492), driven primarily by postprandial blood glucose.
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