Key result
Higher plasma hs-cTnT linked to ~22% greater risk of MACE and all-cause mortality.
Why the study?
Studies evaluating the relationship between hs-cTnT and cardiovascular events have reported controversial results, and cross-sectional or longitudinal follow-up data in the Chinese population were lacking.
Does elevated baseline hs-cTnT predict major adverse cardiovascular events and all-cause mortality in a general Chinese community population?
Cohort (n=1,325)
No
Does elevated baseline hs-cTnT predict major adverse cardiovascular events and all-cause mortality in a general Chinese community population?
Effect estimate: HR 1.223 (95% CI 1.054-1.418)
p-value: p=0.008
Elevated baseline hs-cTnT is an independent predictor of major adverse cardiovascular events and all-cause mortality in a general Chinese community population.
May refine risk stratification in Chinese adults; extends prior evidence to Asian cohorts but leaves causality and practice change open.
Background: The relationship between high-sensitivity cardiac troponin T (hs-cTnT) and different cardiovascular events has been observed in several large community studies, and the results have been controversial. However, there is currently no cross-sectional or longitudinal follow-up study on hs-cTnT in the Chinese population. Methods: We analyzed the association of plasma hs-cTnT levels with major adverse cardiovascular events and all-cause mortality in 1325 subjects from a longitudinal follow-up community-based population in Beijing, China. Results: In the Cox proportional hazards models analysis, the risk of MACE increased with the increase of hs-cTnT levels (HR, 1.223, 95% CI, 1.054–1.418, P = 0.008). Increased hs-cTnT levels were associated with coronary events (HR, 1.391, 95% CI, 1.106–1.749, P = 0.005) in Model 4. Cox proportional risk regression model analysis revealed that increased hs-cTnT levels were associated with an increased risk of mortality (HR, 1.763, 95% CI, 1.224–2.540, P = 0.002), even after adjusting hs-CRP and NT-proBNP. The area under the ROC curve for predicting MACE was 0.559 (95% CI, 0.523–0.595, P = 0.001). The areas under the ROC curve for predicting coronary events and mortality were 0.629 (95% CI, 0.580–0.678, P < 0.001) and 0.644 (95% CI, 0.564–0.725, P < 0.001), respectively. Conclusions: Our findings in the Chinese cohort support that hs-cTnT is a risk factor for major adverse cardiovascular events and all-cause mortality.
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Wang et al. (2020) conducted a cohort in Community-based population (n=1,325). High-sensitivity cardiac troponin T (hs-cTnT) was evaluated on Major adverse cardiovascular events (MACE) (HR 1.223, 95% CI 1.054-1.418, p=0.008). Increased plasma hs-cTnT levels were associated with a higher risk of major adverse cardiovascular events (HR 1.223; 95% CI 1.054-1.418; P=0.008) and all-cause mortality in a Chinese cohort.
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