Key result
Epidural administration of 0.75% ropivacaine with dexmedetomidine significantly reduced the onset time of sensory block to the T10 dermatome (10.02 vs 12.22 minutes) compared to ropivacaine alone.
Why the study?
Various adjuncts have been used to extend the analgesic impact of local anesthetics, prompting a comparative evaluation of epidural ropivacaine alone versus ropivacaine with dexmedetomidine in lower abdominal surgeries.
Does adding dexmedetomidine to epidural ropivacaine improve sensory and motor block characteristics in patients undergoing lower abdominal surgeries?
RCT (n=100)
Single-blind
Randomly allocated
No
Does adding dexmedetomidine to epidural ropivacaine improve sensory and motor block characteristics in patients undergoing lower abdominal surgeries?
Absolute Event Rate: 10.02% vs 12.22%
p-value: p=0.001
Adding dexmedetomidine to epidural ropivacaine significantly prolongs sensory and motor block duration and improves postoperative analgesia without increasing adverse hemodynamic effects.
Supports dexmedetomidine addition to epidural ropivacaine for faster sensory onset in lower abdominal surgery; extends RCT data on regional anesthesia adjuvants.
Background: For the lower abdomen, perineum, and lower limb surgery, spinal anesthetic is the most usually used block. Fentanyl, ketamine, tramadol, neostigmine, magnesium sulfate, and other adjuncts have been used to extend the analgesic impact of local anesthetics. Aim and objective: In this study, We looked for research that compared epidural with 0.75% ropivacaine and 0.75% ropivacaine with dexmedetomidine. The length of sensory and motor block, postoperative analgesia, and adverse effects of epidural anesthesia for lower abdominal procedures were all secondary objectives. Materials and Methods: Following the permission of the Institutional Ethical Committee and valid informed consent from all patients. This research looked at 100 ASA Grade I and II patients who had lower abdomen operations and were between the ages of 20 and 55. The patients were divided into two groups at random. Patients in Group A (n=50) received 20 mL of 0.75 percent Ropivacaine 150 mg epidurally. Patients in Group B (n=50) were given 20ml of 0.75 percent Ropivacaine with dexmedetomidine (1 g/kg body weight). The Student's t-test was used to compare categorical variables between groups.
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Naik et al. (2022) conducted an RCT in Lower abdominal surgeries (n=100). 0.75% Ropivacaine with dexmedetomidine vs. 20 ml of 0.75% Ropivacaine 150mg was evaluated on Onset of sensory analgesia to T10 level (minutes) (p=0.001). Epidural administration of 0.75% ropivacaine with dexmedetomidine significantly reduced the onset time of sensory block to the T10 dermatome (10.02 vs 12.22 minutes) compared to ropivacaine alone.
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