Key result
Damp-heat syndrome in type 2 diabetes was distinguished by 22 differentially abundant metabolites and 15 differentially abundant proteins, predominantly affecting the vitamin metabolism pathway.
Why the study?
Traditional Chinese medicine offers advantages in managing type 2 diabetes mellitus, prompting this study to distinguish patients with or without damp-heat syndrome and discover associated biomarkers using metabolomics-proteomics.
Can metabolomics-proteomics profiles distinguish T2DM patients with or without damp-heat syndrome?
Comparison
T2DM patients with damp-heat syndrome vs without damp-heat syndrome
Authors
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Metabolomics-proteomics differences in damp-heat T2DM are hypothesis-generating; leaves open whether vitamin metabolism pathways merit prospective validation or targeted trials.
Observational (n=60)
Can metabolomics-proteomics profiles distinguish T2DM patients with or without damp-heat syndrome?
Metabolomics and proteomics profiling can identify specific metabolic differences, particularly in vitamin metabolism, to distinguish damp-heat syndrome in patients with type 2 diabetes.
Shao et al. (2023) conducted an observational in Type 2 diabetes mellitus (n=60). Damp-heat syndrome (DHS) vs. Without damp-heat syndrome was evaluated on Differentially abundant metabolites and proteins. Damp-heat syndrome in type 2 diabetes was distinguished by 22 differentially abundant metabolites and 15 differentially abundant proteins, predominantly affecting the vitamin metabolism pathway.
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