Key result
Three days of aspirin administration (1 g twice daily) in healthy men induced gastric damage, increased gastric microbleeding from 0.38 to 7.7 ml/day, and significantly increased mucosal blood flow.
Why the study?
Does aspirin 1 g twice daily for 3 days induce gastric mucosal damage and alter mucosal blood flow and neutrophil activation in healthy male volunteers?
Does aspirin 1 g twice daily for 3 days induce gastric mucosal damage and alter mucosal blood flow and neutrophil activation in healthy male volunteers?
Absolute Event Rate: 7.7% vs 0.38%
Short-term high-dose aspirin administration in healthy volunteers induces significant gastric mucosal damage, microbleeding, and increased mucosal blood flow, potentially mediated by platelet/neutrophil adhesion.
Short-term high-dose aspirin may induce gastric damage in healthy volunteers; leaves open mechanisms and clinical relevance of mucosal blood flow changes.
Gastric and intestinal injury induced by nonsteroidal anti-inflammatory agents (NSAIDs) such as aspirin (ASA) is a common side effect of this class of drugs, but the mechanism by which these drugs act is not fully explained. In this study the effects of 3 days of continuous oral ASA administration (1 g twice daily) to eight healthy male volunteers were studied. To estimate the extent of mucosal damage, gastroscopy was performed before and after 3 days of ASA treatment, during which the mucosal blood flow was measured by means of laser-Doppler flowmetry. Before each endoscopy gastric microbleeding was measured. Since neutrophil activation has recently been suggested to be involved in the pathogenesis of ASA-induced gastric mucosal damage, we examined the influence of ASA treatment on the activation of leukocytes by determining their association with platelets in the blood. Aspirin-induced acute gastric damage reached about 3.5 in the endoscopic Lanza score. Mucosal blood flow increased significantly after ASA treatment, by about 50% in the oxyntic gland area and by 87% in the antral area. Gastric microbleeding rose from about 0.38 ml/day in the intact stomach to about 7.7 ml/day after ASA treatment. The platelet/neutrophil adherence increased significantly in both thrombin-unstimulated and thrombin-stimulated platelets. We conclude that acute 3 days' administration of ASA in man produces well-defined areas of gastric damage accompanied by a significant increase in gastric microbleeding and gastric blood flow and that ASA promotes platelet/neutrophil adhesion that may resemble the neutrophil/endothelium interaction in the gastric mucosa.
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Konturek et al. (1993) studied Healthy volunteers (n=8). Aspirin (ASA) vs. Baseline (before treatment) was evaluated on Gastric microbleeding. Three days of aspirin administration (1 g twice daily) in healthy men induced gastric damage, increased gastric microbleeding from 0.38 to 7.7 ml/day, and significantly increased mucosal blood flow.
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