Key result
Adaptation of a mixture of 2 strains of Type I poliomyelitis virus to PRI mice and cotton rats resulted in a subline completely avirulent for rhesus and cynomolgus monkeys.
Passage of Type I poliomyelitis virus in PRI mice produced a subline that is completely avirulent in monkeys.
A mixture of 2 strains of Type I poliomyelitis virus was adapted to the PRI strain of mice and to cotton rats. The virus could be propagated in certain sublines when either the intraspinal or intracerebral route of inoculation was used. The infectivity of different sublines for mice and cotton rats varied, but the cytopathic titer in tissue culture was of similar magnitude. The passages in PRI mice resulted in a subline completely avirulent for rhesus and cynomolgus monkeys.
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Koprowski et al. (1954) studied Poliomyelitis virus infection. Adaptation of Type I poliomyelitis virus was evaluated on Infectivity and cytopathic titer. Adaptation of a mixture of 2 strains of Type I poliomyelitis virus to PRI mice and cotton rats resulted in a subline completely avirulent for rhesus and cynomolgus monkeys.
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