Key result
Propagation of a poliomyelitic virus strain in monkeys over four years demonstrated a cycle of rising, peaking, and falling virulence, correlating with wave-like fluctuations in human epidemics.
The study demonstrates that the virulence of the poliomyelitis virus fluctuates in cycles during animal passage, which may explain the wave-like fluctuation in epidemics.
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Animal models of poliovirus virulence cycling may parallel epidemic waves; leaves open mechanistic confirmation or surveillance applications in humans.
Flexner et al. (1914) studied Poliomyelitis. Propagation of poliomyelitic virus strain was evaluated on Virulence phases. Propagation of a poliomyelitic virus strain in monkeys over four years demonstrated a cycle of rising, peaking, and falling virulence, correlating with wave-like fluctuations in human epidemics.
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