Key result
Mathematical modeling of HFMD in Shandong, China, demonstrated that the recessive subpopulation plays a critical role in disease spread, and quarantining only the infected is ineffective.
Mathematical modeling suggests that asymptomatic or recessive infections are critical in HFMD transmission, meaning quarantine of symptomatic individuals alone is insufficient for disease control.
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Current HFMD quarantine of symptomatic cases may be insufficient; hypothesis-generating for recessive-targeted interventions.
Ma et al. (2013) studied Hand, foot and mouth disease (HFMD). Recessive infection and quarantine strategies was evaluated on Basic reproduction number and dynamical behaviors. Mathematical modeling of HFMD in Shandong, China, demonstrated that the recessive subpopulation plays a critical role in disease spread, and quarantining only the infected is ineffective.
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