April 1, 1997Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology

Human Herpesvirus-8 (Hhv-8)

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Population

KS-1 cell line, human cord blood mononuclear cells, and human sera

Design

Preclinical

Authors

DAD. V. AblashiUniversity of Nebraska–Lincoln LCLouise G. ChatlynneUniversity of Southern California WLWilliam LappsMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

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Implication

Higher HHV-8 seroprevalence in KS supports association; leaves open causality and clinical utility in Level 5 evidence.

Structured PICO

Population

KS-1 cell line (established from a body cavity lymphoma of an HIV-negative patient), human cord blood mononuclear cells, and human sera (including 21 classic Kaposi's sarcoma [KS] patients, 8 preKS patients, normal adult donors, non-HIV positive homosexuals without KS, HIV-positive patients with KS, and blood donors)

Intervention

Conditioning of KS-1 cells to produce large quantities of infectious HHV-8; development of ELISA and IFA for HHV-8 antibody detection

Outcome

Production of infectious HHV-8 and prevalence/titers of HHV-8 antibodies across different patient populationssurrogate

The successful production of large quantities of infectious HHV-8 from KS-1 cells enabled serological assays demonstrating a significantly higher prevalence and titer of HHV-8 antibodies in Kaposi's sarcoma patients compared to normal populations.

Cite This Study

Ablashi et al. (1997) studied this question.

synapsesocial.com/papers/6a92b6ea8dbb7bc5d5a28546 https://doi.org/10.1097/00042560-199704010-00070

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Human Herpesvirus-8 (Hhv-8)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Human Herpesvirus-8 (Hhv-8)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider