Preclinical study reveals a genetic proximity labelling approach to capture cell-specific secretomes in mice, enabling in vivo tracking of protein secretion during physiological stress.
Secreted proteins regulate a range of physiological functions and pathologies; however, identifying these in vivo has been technically challenging. The article by Plucińska et al. introduces a genetically encoded proximity labelling mouse model, enabling the capture of cell-specific secretomes in plasma and tissue in response to physiological stressors.
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Bowring et al. (2026) studied this question.
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