Key result
BACON therapy in patients with inoperable squamous lung cancer yielded >50% tumor regression in 45% of extensive and 33% of limited disease cases, improving survival over historical controls.
Why the study?
Does the BACON regimen improve tumor regression and survival in patients with inoperable squamous lung cancer?
Population
50 patients with inoperable squamous carcinoma of the lung (38 with extensive, and 12 with limited disease)
Comparison
BACON regimen vs Historical controls receiving supportive care…
Design
Case_series
Authors
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May warrant prospective evaluation of BACON; leaves open efficacy questions given case-report design and historical controls.
Cohort (n=50)
Does the BACON regimen improve tumor regression and survival in patients with inoperable squamous lung cancer?
The BACON regimen demonstrated tumor regression and improved survival compared to historical controls in patients with inoperable squamous lung cancer.
Livingston et al. (1976) conducted a cohort in inoperable squamous carcinoma of the lung (n=50). BACON (bleomycin, adriamycin, CCNU, oncovin and nitrogen mustard) vs. Historical controls (supportive care alone) was evaluated on Tumor regression >50%. BACON therapy in patients with inoperable squamous lung cancer yielded >50% tumor regression in 45% of extensive and 33% of limited disease cases, improving survival over historical controls.
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