Interaction of Adrenal and Gonadal Steroids with Proteins in Human Plasma

MORE than 10 years have elapsed since the initial descriptions of a specific protein in human plasma that binds cortisol (corticosteroid-binding globulin, or CBG) and related adrenal steroids with a high affinity, and in that time much has been learned about the protein and its interaction. The identification of a globulin that binds estradiol and testosterone is a more recent finding, and a firm basis for the existence of this protein was not well established until two or three years ago. Although data have been rapidly accumulating, much less is known about this protein than about CBG. I shall review . . .