Key result
One short cardiac cycle produces a maximum shortening in AV nodal functional refractory period and conduction time, and one normal basic cycle is sufficient to dissipate these effects.
Population
6 anesthetized dogs
Comparison
Introduction of 1 to 6 conditioning short… vs Control
Design
Preclinical
Authors
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No immediate change to clinical AV nodal assessment; leaves open translation of single-cycle effects to human electrophysiology.
In a canine model, a single short cardiac cycle is sufficient to maximally shorten AV nodal refractoriness and conduction time, and a single normal cycle reverses it.
Jacques Billette (1981) studied this question. Short prepremature cycles (PPC) vs. Normal basic cycles was evaluated on Atrioventricular (AV) nodal functional refractory period (FRP) and conduction time (CT). One short cardiac cycle produces a maximum shortening in AV nodal functional refractory period and conduction time, and one normal basic cycle is sufficient to dissipate these effects.
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