Functional Refractory Period of Cardiac Tissues

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Population

Dogs anesthetized with pentobarbital, with the heart denervated, the adrenals ligated, and the S.A. node…

Design

Preclinical

Authors

Discussion

Should not yet inform clinical decisions; leaves open translational relevance of refractory period effects in conduction.

Population

Dogs anesthetized with pentobarbital, with the heart denervated, the adrenals ligated, and the S.A. node crushed

Intervention

Pairs of stimuli (S1-S2) applied to the auricle or ventricle with varying delays

Outcome

Electrophysiological responses (R1-R2 intervals) to paired stimuli (S1-S2) to determine functional refractory periodsurrogate

This preclinical study demonstrates that the functional refractory period causes a delay or stop in impulse conduction in cardiac tissues.

A. Rosenblueth (1958) studied this question.

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