Why the study?
Does a premature stimulus interacting with refractory tissue create reentry in normal canine myocardium?
Population
14 dogs (normal right ventricular myocardium)
Design
Preclinical
Key result
Circus reentry occurs around a critical point where an S2 field of approximately 5 V/cm intersects tissue approximately at the end of its refractory period.
Authors
Loading...
Informs reentry mechanisms in normal myocardium; leaves open translation to clinical arrhythmias.
Does a premature stimulus interacting with refractory tissue create reentry in normal canine myocardium?
Demonstrates that circus reentry can be initiated in normal myocardium when an electrical field intersects tissue at the end of its refractory period, establishing the 'critical point' hypothesis.
Frazier et al. (1989) studied Ventricular fibrillation / Reentry (n=14). Premature (S2) electrical stimulus was evaluated on Potential gradient and preshock interval at the center of the reentrant circuit. Circus reentry occurs around a critical point where an S2 field of approximately 5 V/cm intersects tissue approximately at the end of its refractory period.