September 1, 1996Cardiovascular ResearchOpen Access

Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia

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Structured PICO

Population

Isolated canine right ventricular subepicardium (thin epicardial sheets)

Intervention

Simulated ischemia (hyperkalemic, hypoxic, and acidotic solution) and 4-aminopyridine (transient outward current blocker)

Outcome

Initiation of reentry (phase 2 reentry) and action potential characteristicssurrogate

Phase 2 reentry is implicated as a novel mechanism for the genesis of extrasystoles and initiation of circus movement reentry during simulated ischemia in canine epicardium.

Limitations

Validation of this hypothesis awaits the results of future studies using high-resolution recording techniques

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for phase 2 reentry in ischemic arrhythmias; leaves open translation to human therapies.

Cite This Study

Charles Antzelevitch (1996) studied this question.

synapsesocial.com/papers/6a7da323050e98c0187d82a6 https://doi.org/10.1016/s0008-6363(96)00115-0

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Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider