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The effects of parathyroid hormone (PTH), thyrocalcitonin (TCT) and phosphate ion on the resorption of bone mineral and matrix were studied in cultures of fetal rat long bone. PTH stimulated the release of both pre-incorporated 45Ca and 3H-hydroxyproline. Sustained inhibition of these effects of PTH was obtained by increasing medium phosphate concentration from lmM to 2 or 3 HIM. Addition of TCT to PTH treated bones caused a sharp but transient reduction in PTH stimulated loss of mineral. TCT inhibition of matrix resorption was observed only when TCT was present from the onset of PTH treatment and appeared to be an indirect effect resulting from the block of mineral resorption. (Endocrinology90: 479, 1972)
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Brand et al. (1972) studied this question.
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