Key result
Children with premature adrenarche exhibited early atherosclerotic changes and subclinical cardiac impairment, including increased carotid intima-media thickness and epicardial adipose tissue (p<0.001).
Why the study?
Does premature adrenarche increase surrogate markers of cardiovascular risk in children aged 6-10 years?
Case-Control (n=75)
Does premature adrenarche increase surrogate markers of cardiovascular risk in children aged 6-10 years?
p-value: p=<0.001
Children with premature adrenarche exhibit early atherosclerotic changes and subclinical impairment of cardiac function, suggesting increased early cardiovascular risk.
AIM: The aim of this study was to investigate the cardiovascular risk of children with premature adrenarche (PA). METHODS: A total of 75 children (44 with PA and 31 control subjects) aged 6-10 years were included in the study. Their metabolic, anthropometric, and echocardiographic parameters were recorded and compared. RESULTS: Triglyceride, DHEA-SO4, and 17-hydroxyprogesterone levels were significantly higher in the PA group (p = 0.04, p = 0.002, and p = 0.01, respectively). The echocardiographic assessments revealed that the left ventricular end-diastolic diameter (LVEDD) (p < 0.001), left ventricle (LV) and right ventricle (RV) ejection times (p = 0.031 and p = 0.035, respectively), and LV and RV Tei index measurements (p = 0.033 and p = 0.006, respectively) were significantly higher in the PA group than in the control group, whereas the E/e' ratio of the mitral lateral annulus was significantly lower in the PA group (p = 0.006). Additionally, carotid intima-media thickness and epicardial adipose tissue measurements were significantly increased in the PA group compared to the control group (p < 0.001). CONCLUSION: Early atherosclerotic changes and subclinical impairment of cardiac function were observed in children with PA. It is possible that these children are on a course for early cardiovascular disease.
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Çelik et al. (2016) conducted a case-control in Premature adrenarche (n=75). Premature adrenarche vs. Control subjects without premature adrenarche was evaluated on Cardiovascular risk markers including echocardiographic parameters, carotid intima-media thickness, and epicardial adipose tissue (p=<0.001). Children with premature adrenarche exhibited early atherosclerotic changes and subclinical cardiac impairment, including increased carotid intima-media thickness and epicardial adipose tissue (p<0.001).
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