Key result
BPIP is a highly potent and selective inhibitor of pestivirus replication, with an EC50 of 0.04 µM against BVDV, targeting the viral RNA-dependent RNA polymerase.
Population
In vitro cell cultures infected with pestiviruses and hepaciviruses
Comparison
5-[methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine vs Untreated infected cells or wild-type virus
Design
Preclinical
Authors
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May inform pestivirus antiviral lead development; leaves open in vivo efficacy, safety, and clinical translation.
Effect estimate: EC50 0.04 µM
BPIP is a highly potent and selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase, offering a potential lead for antiviral development.
Paeshuyse et al. (2005) studied Pestivirus infection. BPIP (5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine) vs. Untreated control was evaluated on Inhibition of BVDV-induced cytopathic effect (EC50) (EC50 0.04 µM). BPIP is a highly potent and selective inhibitor of pestivirus replication, with an EC50 of 0.04 µM against BVDV, targeting the viral RNA-dependent RNA polymerase.
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