What question did this study set out to answer?

To determine whether a colorimetric membrane-array detecting circulating tumor cells via a four-mRNA marker panel can identify stage II colorectal cancer patients at high risk of postoperative relapse.

December 1, 2007Annals of Surgery

Prognostic Significance of Multiple Molecular Markers for Patients With Stage II Colorectal Cancer Undergoing Curative Resection

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Authors

YUYih‐Huei UenAsia University SLShiu‐Ru LinNational Academy of Medicine DWDeng‐Chyang WuKaohsiung Medical University

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Implication

Cohort study reveals that a four-marker circulating tumor cell panel predicts postoperative recurrence in stage II colorectal cancer, indicating its utility for identifying high-risk patients.

Key Points

To determine whether a colorimetric membrane-array detecting circulating tumor cells via a four-mRNA marker panel can identify stage II colorectal cancer patients at high risk of postoperative relapse.
Analyzed peripheral blood samples from 194 stage II colorectal cancer patients who underwent curative (R0) resection between January 2002 and December 2005.
Used RT-PCR and colorimetric membrane-arrays to detect mRNA markers for hTERT, CK-19, CK-20, and CEA, with regular postoperative follow-up (median duration: 40 months).
All four mRNA markers were detected in 53 of 194 patients (27.3%), and 56 of 194 patients (28.9%) developed postoperative relapse or metastasis.
Multivariate logistic regression demonstrated that T4 invasion depth (P = 0.013), vascular invasion (P = 0.032), and positive expression of all four mRNA markers (P < 0.001) were independent predictors of postoperative relapse.
Patients positive for any one of these three risk factors demonstrated an increased likelihood of relapse (HR 27.13, 95% CI 11.42–64.40, P < 0.001), with molecular marker detection preceding clinical relapse by a median of 7 months.

Cite This Study

Uen et al. (2007) studied this question.

synapsesocial.com/papers/6a92bbc6e5596d780b1f7f13 https://doi.org/10.1097/sla.0b013e318142d918

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Implication

Cohort study reveals that a four-marker circulating tumor cell panel predicts postoperative recurrence in stage II colorectal cancer, indicating its utility for identifying high-risk patients.

Prognostic Significance of Multiple Molecular Markers for Patients With Stage II Colorectal Cancer Undergoing Curative Resection

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Implication

Key Points

Cite This Study

Prognostic Significance of Multiple Molecular Markers for Patients With Stage II Colorectal Cancer Undergoing Curative Resection

Discussion

Member takes

Implication

Key Points

Cite This Study

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