What does this research mean for the field?

An implantable bioelectronic drug delivery device enables targeted, voltage-controlled release of doxorubicin, demonstrating cytotoxicity in patient-derived glioblastoma models and enhanced drug diffusion in vivo. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To develop and evaluate an implantable bioelectronic device capable of on-demand, voltage-controlled local chemotherapeutic release to bypass the blood-brain barrier in glioblastoma.

August 29, 2026Neuro-Oncology

129 Electroactive drug delivery for local glioblastoma treatment

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Authors

JKJoshua KillileaCancer Research UK IAImmi Van Der Auweraert GSGary Shaw

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Implication

Preclinical study demonstrates voltage-controlled local doxorubicin delivery in glioblastoma models, highlighting a strategy to bypass the blood-brain barrier.

Key Points

To develop and evaluate an implantable bioelectronic device capable of on-demand, voltage-controlled local chemotherapeutic release to bypass the blood-brain barrier in glioblastoma.
Triggered solid-phase doxorubicin release by applying +2V DC for 0.5 hours, measuring release kinetics fluorospectrometrically.
Assessed cytotoxicity and metabolic changes in 2D and 3D patient-derived glioblastoma models using CellTiterGlo and liquid chromatography mass spectrometry.
Evaluated active drug diffusion in an orthotopic SB28 mouse brain tumor model during terminal surgery and in agarose gel tissue phantoms.
Demonstrated voltage-mediated doxorubicin cytotoxicity in 2D and 3D patient-derived glioblastoma cultures, confirming the safety of device materials and electrical stimulation alone in vitro.
Observed greater doxorubicin diffusion in orthotopic mouse brain tumors and agarose gel phantoms under active electrical release compared to passive delivery.

Cite This Study

Killilea et al. (2026) studied this question.

synapsesocial.com/papers/6a92be7b8e5d7d1fc0c122c5 https://doi.org/10.1093/neuonc/noag172.039

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Implication

Preclinical study demonstrates voltage-controlled local doxorubicin delivery in glioblastoma models, highlighting a strategy to bypass the blood-brain barrier.

129 Electroactive drug delivery for local glioblastoma treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

129 Electroactive drug delivery for local glioblastoma treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

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