Response to comment on: “Ligature-induced periodontitis promotes Dnmt3aR878H-driven clonal hematopoiesis”

Qiao Yuan; Min Liao; Fuhua Yan

doi:10.3324/haematol.2026.301816

August 27, 2026HaematologicaOpen Access

Response to comment on: “Ligature-induced periodontitis promotes Dnmt3aR878H-driven clonal hematopoiesis”

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Key Points

Address and clarify methodological critiques regarding how ligature-induced periodontitis enhances the competitive advantage and clonal expansion of Dnmt3aR878H-mutant hematopoietic stem cells.
Re-evaluation of experimental data from murine ligature-induced periodontitis models carrying the Dnmt3aR878H mutation.
Rebuttal addressing alternative interpretations of systemic inflammatory cues, stem cell niches, and bone marrow microenvironment changes.
Reaffirms that chronic periodontal inflammation provides a selective fitness advantage to Dnmt3aR878H-mutated hematopoietic clones.
Maintains that local alveolar bone loss and oral microbial dysbiosis drive systemic cytokine signals that accelerate clonal hematopoiesis.

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Implication

Scientific correspondence clarifies periodontitis-driven Dnmt3a clonal hematopoiesis, highlighting chronic inflammation as a driver of pre-leukemic stem cell expansion.

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Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/6a92be7b8e5d7d1fc0c122f3 https://doi.org/10.3324/haematol.2026.301816

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Response to comment on: “Ligature-induced periodontitis promotes Dnmt3aR878H-driven clonal hematopoiesis”

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Response to comment on: “Ligature-induced periodontitis promotes Dnmt3aR878H-driven clonal hematopoiesis”

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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