Key result
Anticoagulant drugs such as heparin and Dicumarol have an established ability to prevent thrombosis and embolism, though careless administration poses risks.
Anticoagulants such as heparin and Dicumarol are established agents for preventing thrombosis and embolism, though their administration requires care.
Supports cautious anticoagulant use for thrombosis prevention; leaves open optimization versus contemporary agents.
WHEN a blood vessel has been severed the prompt coagulation of blood is an essential safeguard against fatal hemorrhage. Yet the same defense mechanism may itself threaten life through the formation and propagation of an intravascular clot. Although heparin had been employed successfully as early as 1935 to prevent intravascular clotting, its brief duration of action and high cost discouraged general use. The discovery of Dicumarol stimulated enormous interest in the anticoagulant drugs and the ability of these agents to prevent thrombosis and embolism has now been established beyond doubt. It is equally well established that the careless administration of . . .
No takes yet. Share an insight, caveat, or question.
Douglas S. Riggs (1950) conducted a review in Thrombosis and embolism. Anticoagulant drugs (heparin, Dicumarol) was evaluated. Anticoagulant drugs such as heparin and Dicumarol have an established ability to prevent thrombosis and embolism, though careless administration poses risks.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: