Supports postoperative anticoagulant use; extends early observational data but leaves open modern randomized validation.
ANTICOAGULANT treatment is winning for itself a firm place in the armamentarium against postoperative venous thrombosis and pulmonary embolism. This has been accomplished by the sheer weight of accumulating statistics from various clinics, both in this country and in Sweden.1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 Since April, 1941, when dicumarol first became available, the drug has provided the predominant method of therapy at the Lahey Clinic. In the majority of cases a combination of heparin and dicumarol has been used. During the first four years heparin was given by continuous intravenous drip to cover the latent period of dicumarol. For the past two years deep . . .
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Evans et al. (1948) studied this question.
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