Key result
Moderate alcohol consumption (30 g) increased postprandial platelet aggregation and PAI activity while reducing t-PA activity, with effects mainly seen in the older age group.
Why the study?
Does moderate alcohol consumption affect platelet function, t-PA, and PAI in healthy males?
Does moderate alcohol consumption affect platelet function, t-PA, and PAI in healthy males?
Moderate alcohol consumption transiently impairs fibrinolysis and increases platelet aggregation postprandially, particularly in older individuals.
May warrant postprandial caution with moderate alcohol in older adults; hypothesis-generating for age-specific hemostatic effects.
Short-term effects of moderate alcohol consumption on platelet function, tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) were studied in two age groups of volunteers (20-30 and 45-55 years), each consisting of eight healthy males. The alcohol (30 g in red port and wine) was consumed during a standard dinner. Two blood samples were drawn: one in the postprandial phase, and one the next morning after fasting overnight. Alcohol consumption tended to increase platelet aggregation and production of hydroxy fatty acids, reduced plasma t-PA activity and increased PAI activity in the postprandial phase. After the overnight fast the effects on t-PA and PAI had disappeared whereas at that time alcohol consumption tended to decrease platelet function. The effects of alcohol on t-PA and PAI activity appeared mainly in the older age group, whereas the t-PA activity in this group was already much lower, irrespective of alcohol consumption.
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Veenastra et al. (1990) studied Healthy (n=16). Moderate alcohol consumption was evaluated on Platelet function, tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI). Moderate alcohol consumption (30 g) increased postprandial platelet aggregation and PAI activity while reducing t-PA activity, with effects mainly seen in the older age group.
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