WHILE THE normal pattern of androgen and estrogen excretion by the human kidney is gradually becoming clearer, the sources of the various constituents are still in part obscure and the amounts of testis secretion required to produce normal amounts of biologically active excretion products are not well known. A few studies on recovery of injected androgens in man are available. Kochakian (1) administered urinary extracts to one normal and to one castrate man. In the normal, injections of 11 to 17 capon units (his own unit) on two occasions caused no apparent increase in androgen excretion in the urine. In the castrate the injection of 30 to 40 capon units per day for 10 days was followed by a recovery of 3% of the injected activity from the urine passed during this period.
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Hoskins et al. (1939) studied this question.