Cutaneous epithelioid angiosarcoma can cytologically mimic poorly-differentiated carcinoma or melanoma, requiring immunohistochemical and ultrastructural examination for accurate diagnosis.
Accurate differentiation of cutaneous epithelioid angiosarcoma requires IHC and ultrastructure; leaves open validation in larger diagnostic series.
We report on the cytologic features of a rare case of cutaneous epithelioid angiosarcoma of the scalp occurring in a 65-yr-old Chinese male. The prominent epithelioid features may cytologically mimic poorly-differentiated carcinoma, malignant melanoma, and even epithelioid sarcoma. Recognition of subtle cytologic features of vasoproliferation, immunohistochemical demonstration of endothelial markers, and ultrastructural examination are necessary before a final conclusion may be drawn.
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Ng et al. (1997) studied this question.
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