Key result
Patients with idiopathic dilated cardiomyopathy had a significantly lower average total blush score compared to controls (7.6 vs. 8.8; P<0.0001).
Why the study?
Is total blush score (TBS) reduced in patients with idiopathic dilated cardiomyopathy compared to controls, and does it correlate with disease severity?
Case-Control (n=52)
Is total blush score (TBS) reduced in patients with idiopathic dilated cardiomyopathy compared to controls, and does it correlate with disease severity?
Absolute Event Rate: 7.6% vs 8.8%
p-value: p=<0.0001
Total blush score is significantly reduced in idiopathic dilated cardiomyopathy and correlates with disease severity, suggesting it may serve as a surrogate marker for microvascular dysfunction.
Hypothesis-generating for microvascular dysfunction in idiopathic dilated cardiomyopathy; prospective validation of total blush score needed.
BACKGROUND: The aim of this study was to evaluate tissue-level perfusion in patients with idiopathic dilated cardiomyopathy (IDC), using the myocardial blush grade technique. METHOD: The study population consisted of 26 prospectively enrolled IDC patients (15 women and 11 men; mean age, 59+/-8.8 years) and 26 control subjects (11 women and 15 men; mean age, 54.9+/-10.6 years), whose angiographic films were technically adequate for myocardial blush grade analysis. After grading, we measured total blush score (TBS) for both groups. TBS was determined as the sum of the blush grades of each coronary territory. RESULTS: A total of 156 coronary territories in both groups were assessed. Average of TBS was significantly lower in patients with IDC than in control group (7.6+/-1.2 vs. 8.8+/-0.4; P<0.0001). The TBS significantly and inversely correlated with New York Heart Association class, heart rate, left ventricular end-systolic dimension, and left ventricular end-diastolic pressure, and positively correlated with left ventricular ejection fraction (r=-0.76, P<0.001; r=-0.61, P=0.001; r=-0.77, P<0.0001; r=-0.68, P<0.0001; and r=0.67, P<0.0001, respectively). CONCLUSION: In IDC, decreased TBS might be assumed to be a surrogate marker for a diseased microvascular network in the catheterization laboratory. The relationship between reduced TBS and IDC severity suggests that this index might have prognostic significance.
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Atmaca et al. (2008) conducted a case-control in Idiopathic dilated cardiomyopathy (n=52). Idiopathic dilated cardiomyopathy vs. Control subjects was evaluated on Total blush score (TBS) (p=<0.0001). Patients with idiopathic dilated cardiomyopathy had a significantly lower average total blush score compared to controls (7.6 vs. 8.8; P<0.0001).
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