Idiopathic dilated cardiomyopathy was associated with significantly impaired myocardial blood flow reserve compared to healthy subjects (2.19 vs 3.51, P < 0.05).
Observational (n=19)
Is myocardial blood flow reserve impaired in patients with idiopathic dilated cardiomyopathy compared to healthy subjects when measured by velocity-encoded cine MRI?
Velocity-encoded cine MRI demonstrates that myocardial blood flow reserve is significantly reduced in patients with idiopathic dilated cardiomyopathy, indicating impaired coronary microcirculation.
Absolute Event Rate: 2.19% vs 3.51%
p-value: p=< 0.05
PURPOSE: To quantify global myocardial perfusion using magnetic resonance imaging (MRI) in patients with heart failure due to idiopathic dilated cardiomyopathy (IDC) and to compare myocardial perfusion and microvascular reactivity with healthy subjects. MATERIALS AND METHODS: A total of 19 subjects (healthy volunteers (N = 12) and IDC patients (N = 7)) were studied using cine MRI to measure left ventricular (LV) mass and a velocity-encoded cine MRI technique to measure coronary sinus flow at rest and after dipyridamole-induced hyperemia. Absolute values of total myocardial blood flow (MBF) were calculated from coronary sinus flow and LV mass. RESULTS: At baseline, MBF was not significantly different in patients with IDC (0.48 +/- 0.07 mL/minute/g) and healthy subjects (0.55 +/- 0.19 mL/minute/g, P= 0.41). After dipyridamole administration, MBF in IDC patients increased to a level significantly less than that in normal volunteers (1.05 +/- 0.35 mL/minute/g vs. 1.99 +/- 1.05 mL/minute/g, P < 0.05). Consequently, MBF reserve was impaired in patients with IDC (2.19 +/- 0.77) compared to that in healthy subjects (3.51 +/- 1.29, P < 0.05). A moderate correlation was found between MBF reserve and LV ejection fraction (r = 0.48, P < 0.05). CONCLUSION: MBF reserve is reduced in patients with IDC, indicating that coronary microcirculatory flow is impaired. This integrated MRI approach allows quantitative measurement of global MBF in humans and may have the potential to study the effects of pharmacological interventions on myocardial perfusion.
Watzinger et al. (Fri,) conducted a observational in Idiopathic dilated cardiomyopathy (n=19). Idiopathic dilated cardiomyopathy vs. Healthy volunteers was evaluated on Myocardial blood flow (MBF) reserve (p=< 0.05). Idiopathic dilated cardiomyopathy was associated with significantly impaired myocardial blood flow reserve compared to healthy subjects (2.19 vs 3.51, P < 0.05).
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