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August 1, 2000HeartOpen Access

Double blind randomised placebo controlled trial of adjunctive prednisolone in the treatment of effusive tuberculous pericarditis in HIV seropositive patients

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Why the study?

Does adjunctive prednisolone reduce mortality and improve clinical outcomes in HIV seropositive patients with effusive tuberculous pericarditis?

Population

58 HIV seropositive patients aged 18-55 years with effusive tuberculous pericarditis.

Comparison

Prednisolone for six weeks added to standard… vs Placebo for six weeks added to standard short…

Design

RCT, randomly assigned, Double blind

Follow-up

18 months

Authors

JHJames HakimTwitter (United States)

Discussion

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Implication

Supports adjunctive prednisolone in HIV-positive effusive TB pericarditis; confirms mortality benefit in this population.

Structured PICO

Does adjunctive prednisolone reduce mortality and improve clinical outcomes in HIV seropositive patients with effusive tuberculous pericarditis?

P
Population
58 HIV seropositive patients aged 18-55 years with effusive tuberculous pericarditis.
I
Intervention
Prednisolone for six weeks added to standard short course antituberculous chemotherapy.
C
Comparator
Placebo for six weeks added to standard short course antituberculous chemotherapy.
O
Outcome
Clinical improvement, echocardiographic and radiologic pericardial fluid resolution, and death at 18 months follow up.hard clinical

Adjunctive prednisolone significantly reduces mortality and accelerates clinical improvement in HIV-positive patients with effusive tuberculous pericarditis.

Cite This Study

James Hakim (2000) studied this question.

synapsesocial.com/papers/6a92c4c4e5596d780b1f835dhttps://doi.org/10.1136/heart.84.2.183
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tuberculous Pericarditis1991 · 162 citations
  2. 2Use of Prednisolone in the Treatment of HIV-positive Tuberculosis Patients1992 · 45 citations