Key result
Coronary perfusion maintained uniform actin-activated ATPase activity in rat myocardial cells, whereas superfusion resulted in nonuniform activity, suggesting regulation by blood vessel-derived factors.
Contractile proteins in myocardial cells appear to be regulated by a substance produced by blood vessels in proportion to local oxygen tension.
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Does not inform clinical practice; leaves open whether vessel-derived factors regulate human myocardial ATPase activity.
McClellan et al. (1992) studied this question. Coronary perfusion vs. Superfusion was evaluated on Calcium- and actin-activated myosin ATPase activities. Coronary perfusion maintained uniform actin-activated ATPase activity in rat myocardial cells, whereas superfusion resulted in nonuniform activity, suggesting regulation by blood vessel-derived factors.
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