New stereogenic centers are generated in the [TiCl2(OiPr)2]-catalyzed reaction of [(S)R]-[(p-tolylsulfinyl)methyl]-p-quinamines 1 with α,β-unsaturated ketones 2 to give hydroindole-substituted systems 3 in a domino process. Up to four stereogenic centers are formed in the reaction of cycloalkenones and up to five when acyclic enones (2 equiv) are used.
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Carreño et al. (2002) studied this question.