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Systematic review finds uncertain evidence that antibiotics for Streptococcus A skin infections prevent acute rheumatic fever, highlighting rising antimicrobial resistance.
Objectives: skin infections prevents ARF/RHD. Methods: and clinical resolution of polymicrobial infections with antibiotics through December 13, 2024. We calculated risk ratios and absolute risk differences, using the grading of recommendations, assessment, development, and evaluation (GRADE) to assess the certainty of evidence. Results: Benzathine benzylpenicillin-associated injection-site pain and oral antibiotic-associated gastrointestinal disorders were commonly reported. Conclusions: skin infections to prevent ARF/RHD is uncertain, requiring further research, with consideration of antimicrobial resistance and the limited antibiotic pipeline.
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Leong et al. (2025) studied this question.
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