Key result
Fluoxetine and other SSRIs may promote atherogenesis and impair cerebromicrovascular autoregulation in geriatric patients, potentially increasing the risk of adverse cardiovascular events.
Why the study?
SSRIs are frequently prescribed for geriatric depression, but increasing evidence suggests they exert cardiovascular side effects and that aging may increase their plasma levels.
Do fluoxetine and other SSRIs increase cardiovascular and cerebrovascular risks in geriatric patients with depression?
Do fluoxetine and other SSRIs increase cardiovascular and cerebrovascular risks in geriatric patients with depression?
SSRIs, commonly prescribed for geriatric depression, may have underappreciated cardiovascular and cerebrovascular side effects in older adults due to altered pharmacokinetics and off-target vascular effects.
Should not yet alter SSRI prescribing in geriatric depression; hypothesis-generating for vascular risks needing prospective trials.
Late life depression is an important public health problem, which associates with increased risk of morbidity and mortality. Selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, are often prescribed to treat geriatric depression. There is increasing evidence that fluoxetine and other SSRIs exert a wide range of cardiovascular side effects. Furthermore, there is evidence that aging may increase plasma level of SSRIs. In this overview, the potential role of side effects of treatment with fluoxetine and other SSRIs in the pathogenesis of age-related cardiovascular diseases, including atherogenesis, cardiac pathologies, and cerebromicrovascular impairment, is discussed.
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Ungvári et al. (2019) conducted a review in Geriatric depression. Fluoxetine and other SSRIs was evaluated. Fluoxetine and other SSRIs may promote atherogenesis and impair cerebromicrovascular autoregulation in geriatric patients, potentially increasing the risk of adverse cardiovascular events.
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