Key result
Disintegration of lipid rafts with methyl-beta-cyclodextrin completely abolished the cardioprotective effects of ischemic preconditioning in rat hearts.
Why the study?
Does the disintegration of lipid rafts with methyl-beta-cyclodextrin abolish the cardioprotective effects of ischemic preconditioning in rat hearts?
Population
Rat hearts perfused by working mode
Comparison
Methyl-beta-cyclodextrin administered during… vs Ischemic preconditioning in the absence of…
Design
Preclinical
Authors
Loading...
Lipid rafts may mediate ischemic preconditioning in rats; leaves open whether raft-targeted strategies warrant human translation.
Does the disintegration of lipid rafts with methyl-beta-cyclodextrin abolish the cardioprotective effects of ischemic preconditioning in rat hearts?
Lipid rafts are essential for generating survival signals during ischemic preconditioning, and their disruption completely abolishes cardioprotection against ischemia-reperfusion injury.
Das et al. (2008) studied Ischemia reperfusion injury. Methyl-beta-cyclodextrin vs. Preconditioning without Methyl-beta-cyclodextrin was evaluated on Cardioprotection (ventricular performance, myocardial infarct size, cardiomyocyte apoptosis). Disintegration of lipid rafts with methyl-beta-cyclodextrin completely abolished the cardioprotective effects of ischemic preconditioning in rat hearts.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: