Why the study?
Does ischemic preconditioning improve postischemic myocardial function and reduce tissue injury via tyrosine kinase-phospholipase D and MAP kinase pathways in isolated rat hearts?
Population
Isolated working rat hearts
Comparison
Ischemic preconditioning with or without 100… vs Perfused with buffer only for 60 min (control)
Design
Preclinical
Follow-up
30 min ischemia followed by 30 min reperfusion
Authors
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Tyrosine kinase-PLD-MAPK signaling may mediate preconditioning cardioprotection in rat hearts; hypothesis-generating, requires validation before clinical relevance.
Does ischemic preconditioning improve postischemic myocardial function and reduce tissue injury via tyrosine kinase-phospholipase D and MAP kinase pathways in isolated rat hearts?
Ischemic preconditioning improves postischemic myocardial function in rat hearts through a signaling pathway involving tyrosine kinase, phospholipase D, and multiple protein kinases including MAP kinases.
Maulik et al. (1996) studied this question.
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