January 1, 1995AJP Heart and Circulatory Physiology
Does protein kinase C play a role in ischemic preconditioning in rat hearts?
Why the study?
Does inhibition of PKC with calphostin C block the cardioprotective effects of ischemic preconditioning in rat hearts?
Population
Rat model undergoing 90 min of coronary occlusion followed by 4 h of reperfusion
Comparison
Calphostin C with or without ischemic… vs Vehicle with or without ischemic preconditioning
Design
Preclinical
Follow-up
4 hours of reperfusion
Authors
Discussion
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Member takes
Implication
Calphostin C leaves infarct size unchanged in nonpreconditioned rat hearts; leaves open PKC's role in ischemic preconditioning.
Structured PICO
Does inhibition of PKC with calphostin C block the cardioprotective effects of ischemic preconditioning in rat hearts?
P
Population
Rat model undergoing 90 min of coronary occlusion followed by 4 h of reperfusion
I
Intervention
Calphostin C (0.1 mg/kg IV boluses) with or without ischemic preconditioning (three 3-min episodes of ischemia and 5 min of reperfusion)
C
Comparator
Vehicle with or without ischemic preconditioning
O
Outcome
Myocardial infarct size expressed as a percentage of the area at risksurrogate
Inhibition of PKC with calphostin C does not affect infarct size in nonpreconditioned rat hearts, as part of an investigation into its role in ischemic preconditioning.
Cite This Study
Li et al. (1995) studied this question.