Delayed cytoprotection from ischaemic preconditioning in rabbit myocardium involves early activation of protein kinase C.
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Supports PKC mediation of delayed preconditioning in rabbits; hypothesis-generating for human cardioprotection, should not change practice.
Rabbit hearts were preconditioned with four 5 min coronary artery occlusions 24 h before 30 min coronary occlusion with 120 min reperfusion. Preconditioning significantly reduced the percentage of myocardium infarcting within the risk zone from 49.1 +/- 4.3% to 31.8 +/- 3.5% (P < 0.05). When the protein kinase C (PKC) inhibitor, chelerythrine, was administered just before preconditioning, the delayed protection against infarction 24 h later was abolished. We conclude that the delayed cytoprotective response associated with ischaemic preconditioning of myocardium is likely to involve the early activation of one or more PKC subtypes.
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Baxter et al. (1995) studied this question.
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