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December 24, 2020MetabolitesOpen Access

Nocturnal hypoglycemia in pediatric patients with type 1 diabetes was associated with significantly higher median heart rates in the hour preceding the episode in 67% of affected subjects.

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Why the study?

The study evaluated whether combining blood glucose and heart rate measurements to investigate heart rate changes related to nocturnal hypoglycemia in pediatric type 1 diabetes could improve hypoglycemia prediction.

Does continuous heart rate monitoring detect physiological changes prior to nocturnal hypoglycemia in children and adolescents with type 1 diabetes?

Comparison

HR recorded in the hour before nocturnal hypoglycemia vs sleep intervals without hypoglycemia

Design

Exploratory observational study

Follow-up

Average 194 days

Key result

Nocturnal hypoglycemia in pediatric patients with type 1 diabetes was associated with significantly higher median heart rates in the hour preceding the episode in 67% of affected subjects.

Authors

VCValeria CalcaterraPBPietro BosoniLSLucia Sacchi

Discussion

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Member takes

Overview

Heart rate monitoring may aid nocturnal hypoglycemia prediction in pediatric type 1 diabetes; hypothesis-generating, needs prospective trials before adoption.

Study Design

Type

Observational (n=17)

Structured PICO

Does continuous heart rate monitoring detect physiological changes prior to nocturnal hypoglycemia in children and adolescents with type 1 diabetes?

P
Population
17 children and adolescents with type 1 diabetes monitored with continuous glucose and heart rate devices for an average of 194 days.
E
Exposure
Continuous monitoring using flash glucose monitoring devices for blood glucose and wrist-worn fitness trackers for heart rate
C
Comparator
Intra-subject comparison of heart rate values recorded during sleep intervals without hypoglycemia
O
Outcome
Difference in heart rate (HR) values recorded in the hour before nocturnal hypoglycemia (NH) episodes compared to sleep intervals without hypoglycemiasurrogate

Heart rate modifications, specifically an elevated median heart rate, occur prior to nocturnal hypoglycemia in pediatric patients with type 1 diabetes, suggesting wearable fitness trackers could aid in early detection.

Cite This Study

Calcaterra et al. (2020) conducted an observational in Type 1 diabetes (n=17). Nocturnal hypoglycemia vs. Sleep intervals without hypoglycemia was evaluated on Heart rate changes in the hour before nocturnal hypoglycemia compared to sleep intervals without hypoglycemia. Nocturnal hypoglycemia in pediatric patients with type 1 diabetes was associated with significantly higher median heart rates in the hour preceding the episode in 67% of affected subjects.

synapsesocial.com/papers/6a92d0cb6a4f73282e184e47https://doi.org/10.3390/metabo11010005
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