Key result
Consumption of a high-fat diet protected mice from ventilator-induced lung injury, attenuating deteriorations in respiratory mechanics and pulmonary edema through neutrophil-independent mechanisms.
Why the study?
Does a high-fat diet protect mice from ventilator-induced lung injury?
Does a high-fat diet protect mice from ventilator-induced lung injury?
Consumption of a high-fat diet protects mice from ventilator-induced lung injury via neutrophil-independent mechanisms, potentially explaining the clinical 'obesity paradox' observed in ARDS patients.
May explain obesity paradox in ARDS; leaves open translation of high-fat protection to human ventilator-induced lung injury.
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Wilson et al. (2017) studied Ventilator-induced lung injury. High fat diet vs. Control diet (7.4% fat) was evaluated on Ventilator-induced lung injury (respiratory mechanics, blood gases, pulmonary edema). Consumption of a high-fat diet protected mice from ventilator-induced lung injury, attenuating deteriorations in respiratory mechanics and pulmonary edema through neutrophil-independent mechanisms.
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